Growth in patients with isolated gonadotrophin
نویسندگان
چکیده
The growth pattern of 66 patients (50 males, 16 females) with isolated gonadotrophin deficiency (IGnD), who had reached their final height with epiphyseal closure, was evaluated. For the purpose of analysis the males were divided into two groups according to age at referral: group 1 <16 years (n=23) and group 2 ,16 years (n=27). Sex hormone treatment was initiated at a mean (SD) chronological age of 15-8 (1-3) and 18-6 (1-2) years in groups 1 and 2 in the males and at 15-3 (1.3) years in the females. The duration of treatment (until epiphyseal closure) in the males was 3 9 (1-5) years in group 1 and 2-1 (1.0) years in group 2 and 2-8 (1-3) years in the females. There was no significant difference between the mean final height in groups 1 and 2, but it was significantly higher than the mean parental height (mean height SD score (HtSDS): 0.1 (1-1) v -0-8 (0.9)) and they were significantly correlated. For females the mean HtSDS compared with parental height was 0-4 (1-5) v
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